www亚洲无 码A片,性猛交一级A片少妇视频无码,最好看的2018中文在线观看,欧美性猛交XXXX乱大交3

Vascular Health is Associated with Amyloid- in Cognitively Normal Older Adults

Journal of Alzheimer’s Disease 70 (2019) 467–475 DOI 10.3233/JAD-181268

Yumei Liua, Sophy J. Perdomoa, Jaimie Warda, Eric D. Vidonib, Jason F. Sisantea,c,Kiersten Kirkendolla, Jeffrey M. Burnsb and Sandra A. Billingera,?

a Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center,Kansas City, KS, USA
b University of Kansas Alzheimer’s Disease Center, Fairway, KS, USA
c Department of Physical Medicine and Rehabilitation, University of Kansas Medical Center, Kansas City,KS, USA

Abstract.
Background: Vascular health is closely related to Alzheimer’s disease (AD). Vascular function measured by flow mediated dilation (FMD) or pulsatility index (PI) can be used as marker of peripheral and central vascular health but is poorly characterized in those at risk for AD.
Objective: To assess the relationship of peripheral and central vascular function with amyloid- (A) and white matter lesion burden among cognitively normal older adults.
Methods: We enrolled participants 65 years of age and older. Using Doppler ultrasound, we assessed brachial artery FMD,and middle cerebral artery (PI). Global A burden, quantified using [18F] Florbetapir PET imaging, and white matter lesion volume (WML) were used as measures of AD pathology and vascular brain injury.
Results: After adjusting for age and cardiovascular risk factors, the data (n = 83) showed a negative association between FMD and A burden ( = –0.03, p < 0.001). FMD at a cut-off of 4.45% had 88% specificity and 75% sensitivity to elevated A (AUC= 0.86, 95%CI: 0.77–0.95). FMD was not related to WML volume (p = 0.8), and PI was unrelated to A burdenor WML volume (0 > 0.4).
Conclusions: Among cognitively normal older adults, blunted peripheral vascular function, as measured by brachial artery FMD, is associated with A burden. These findings provide support for further exploration into the pathophysiological relationship of vascular health and AD risk as measured by A.
Keywords: Amyloid- protein, pulsatile flow, transcranial doppler sonography, vascular endothelium

Vascular Health is Associated with Amyloid-β in Cognitively Normal Older Adults..pdf

91丨夜色丨精品入口 | 欧美被操一区二区三区 | 亚洲国产精品视频一区二区三区 | 少妇激情免费A片 | 性视频日韩无码四区 | 日韩AV无码国产 | 60岁老熟女一区二区三区四区 | 国产无遮挡又黄又大又爽 | 爱草在线视频观看 | 中文字幕一区二区三区第10页 | 亚洲精品一区二区三区免大胸 | 日韩无码专区免费观看 | 国产精品精品一区 | 中文字幕一区二区三区电影 | 一本道人精品区一区 | 无码毛片一区二区三区人口 | 久久综合无码内射国产 | 免费无码婬片AAAA片直播 | 国产真实乱人偷精品人妻 | 高清免费观看无码 | 动漫无码在线播放 | 国产无码黄色视频 | 亚洲喷水无码一区丰满爆乳少妇 | 啊灬用力灬啊灬啊灬啊灬A片小 | 潮喷大喷水免费在线 | 无码内射视频免费在线观看 | 国产在线成人视频 | 强推少妇人妻视频在线 | 水户香奈人妻中文字幕 | 国产一a毛一a毛A免费看图 | 99久久爽爽无码人妻AⅤ | 欧美一区二区无码视频 | 国产一级特黄aaa大片 | 黑人无码一区二区三区在线观看 | 亚洲欧美婷婷五月色综合 | 久久精品国成一区二区三区 | 中文字幕一区二区在线观看 | 国产又爽又黄无码无遮挡老牛影视 | 丰满少妇xxxxx高清视频 | 国产高清自拍后入内裤 | 亚洲成a人片7777777影片 |